She appeared on a handful of mid-1980s television series such as Growing Pains and the short-lived Fast Times, as well as made-for-television films like The Thanksgiving Promise and Infidelity before landing a regular spot in the sitcom that lasted only a few episodes Day by Day with Douglas Sheehan, Linda Kelsey and Julia Louis-Dreyfus. From 1992 to 1997 her first television role in a starring role was as Alison Parker in Melrose Place. At the time, in 1995, she starred in a television movie that was made to be made Beauty's Revenge which was also promoted in DVD and CD form under the name "Midwest Obsession". After that, she went on to portray Georgia Thomas on Ally McBeal from 1997 to 2000. Thorne-Smith auditioned initially for the title role on the show, but it ultimately went to Calista Flockhart. Her character was written out of Ally McBeal at the beginning of season four in 2000 although she made occasional guest appearances afterward. Later, she said that she left the show partly due to the pressure to be thin. "I started undereating, overexercising and pushing myself too hard and brutalizing my body's immune system," she told US Weekly. "The amount of time consumed by food and feeling upset over my body was insane. "From 2001 to 2009, she starred as Cheryl on According to Jim. In 2007, her pregnancy was kept from the show at first, but was then included in the plot. She was cast as Alan Harper's love interest Lyndsey McElroy in season seven, Two and a Half Men on February 18 in 2010. She appeared in 52 episodes from season seven to twelve.
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